![]() ![]() Evidence for complete LS development was supported by the transition to blood-stage infection in mice engrafted with human erythrocytes. Ectopic huLiver tumors were generated through subcutaneous injection of the HC-04 cell line and shown to be infectible by both freshly dissected sporozoites and through the bite of infected mosquitoes. ![]() Reported here is a reproducible, easy-to-manipulate, and moderate-cost in vivo model to study human Plasmodium LS in mice the ectopic huLiver model. ![]() However, limited understanding of infection dynamics in human LS exists due to species-specificity challenges. vivax infection requires parasite replication within host hepatocytes, referred to as liver stage (LS). ![]()
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